Paul S. Horn, PhD

Biostatistician, Division of Neurology
Professor, UC Department of Pediatrics

paul.horn@cchmc.org

About

Biography

My area of research is statistical analysis and how to apply general statistical methodology to specific pediatric problems. I want to improve statistical analysis in pediatrics to provide more reliable evidence for decision making.

I am interested in providing answers to questions regarding the statistical methodology that applies to pediatric populations, such as appropriate reference ranges. One of my achievements is the development of quantile estimators that are relatively robust for smaller sample sizes.

I am a member of the International Committee for the Clinical and Laboratory Standards Institute. My career spans more 39 years, and I have worked at Cincinnati Children’s since 2013. My research has been published in various respected journals, including Interdisciplinary Neurosurgery, Advanced Techniques and Case Management, Neuroscience, Frontiers in Integrative Neuroscience, Muscle and Nerve, and Neurology.

Services and Specialties

Neurology

Interests

Robustness; nonparametrics; statistical computing; simulations; reference intervals.

Research Areas

Neurology

Publications

Extensive ischemic change on stroke presentation is uncommon: A population-based study. Aziz, YN; Vagal, A; Sucharew, H; Williamson, BJ; Khandwala, V; Wang, L; Cornelius, R; Gaskill-Shipley, MF; Tomsick, TA; Wang, DT; Stanton, RJ; Mistry, EA; Kissela, B; Khatri, P. Journal of Stroke and Cerebrovascular Diseases. 2025; 34:108488.

Study protocol for a randomized controlled trial of Regulating Together (RT), a group therapy for emotion dysregulation in school-age autistic youth and their caregivers. McKinney, WS; Tadevich, LJ; Schmitt, LM; Horn, PS; Ruberg, JR; White, SW; Reisinger, DL; Burkett, KW; Sarawgi, S; Kang, S; Shaffer, RC. BMC Psychology. 2025; 13:436.

Projecting US Population Eligibility for Minimally Invasive Surgical Evacuation of Intracerebral Hemorrhage. Wechsler, PM; Sucharew, H; Robinson, DJ; Stanton, RJ; Aziz, YN; Prestigiacomo, C; Demel, SL; Horn, P; Maloney, TC; Williamson, BJ; Flaherty, ML; Mistry, EA; Vagal, A; Khatri, P. Stroke. 2025; 56:3532-3537.

Elevated Levels of Active GSK3β in the Blood of Patients with Myotonic Dystrophy Type 1 Correlate with Muscle Weakness. Jennings, K; Tian, C; Brown, RL; Horn, PS; Schoser, B; Kushlaf, H; Timchenko, NA; Timchenko, L. International Journal of Molecular Sciences. 2025; 26:10760.

Behavior-iEEG-Spectral-Power-Correlation: Defining Neural Substrates of Naturalistic Behavior. Ervin, B; Frink, C; Buroker, J; Horn, PS; Byars, AW; Scholle, C; Greiner, HM; Mangano, FT; Holland, KD; Hickok, G; Crone, NE; Arya, R. Annals of Neurology. 2025; 98:1096-1110.

FX ENTRAIN: scientific context, study design, and biomarker driven brain-computer interfaces in neurodevelopmental conditions. Citarella, J; Siekierski, P; Ethridge, L; Westerkamp, G; Liu, Y; Blank, E; Voorhees, L; Batterink, L; Jones, SR; Smith, E; Horn, PS; De Stefano, LA; Erickson, CA; Pedapati, EV. Frontiers in Neuroscience. 2025; 19:1618804.

Brief Report: A Double-Blind, Placebo-Controlled, Crossover, Proof-of-Concept Study of Minocycline in Autism Spectrum Disorder. Erickson, CA; Shaffer, RC; Will, M; Schmitt, LM; Horn, P; Hirst, K; Pedapati, EV; Ober, N; Tumuluru, RV; Handen, BL; Beversdorf, DQ. Journal of Autism and Developmental Disorders. 2025; 55:3387-3394.

637PAssessment of transition readiness for pediatric patients with Duchenne muscular dystrophy. Vilaisaktipakorn, P; Sawnani, A; Gurbani, N; Pascoe, J; Stewart, C; Horn, P; Bange, J; Zygmunt, A; Tian, C. Neuromuscular Disorders. 2025; 53:106171.

186PPerformance of upper limb in steroid-treated Duchenne muscular dystrophy: genotype-phenotype correlations. Wade, C; Zygmunt, A; Horn, P; Bonarrigo, K; Reebals, L; Rybalsky, I; Tian, C. Neuromuscular Disorders. 2025; 53:105539.

Reliability of short interval cortical inhibition in children with attention deficit hyperactivity disorder. Gilbert, DL; Huddleston, DA; Migneault, KY; Crocetti, D; Horn, PS; Wu, SW; Mostofsky, SH. Clinical Neurophysiology. 2025; 175:2110750.